The recently developed CRISPR screen technology, based on the CRISPR/Cas9 genome editing system, enables genome-wide interrogation of gene functions in an efficient and cost-effective manner.Although many computational algorithms and web servers have been developed to design single-guide RNAs (sgRNAs) with high specificity and efficiency, algorithm
Abstract Background Preoperative anxiety and physical unfitness have been shown to have adverse effects on recovery from cardiac surgery.This study involving cardiac surgery patients was primarily aimed at assessing the feasibility of delivering physical conditioning and stress reduction programs within the public hospital setting.Secondary aims we
BackgroundVarious enhanced patient instructions (EPIs) have been used for bowel preparation (BP) and our previous meta-analysis also demonstrated the efficacy of EPIs in increasing the colonic polyp and adenoma detection rates; however, the optimal method for adequate BP has not yet been developed.ObjectiveWe performed a network meta-analysis to de
Abstract Background Borassus flabellifer or Asian Palmyra palm is an important crop for local economies in the South and Southeast Asia for its fruit and palm sugar production.Archeological and historical evidence indicated the presence of this species in Southeast Asia dating back at least 1500 years.B.flabellifer is believed to be originated in A
Tagging studies have been widely conducted to investigate the movement pattern of wild fish populations.In this study, we present a set of length-based, age-structured Bayesian hierarchical models to explore variabilities and uncertainties in modeling tag-recovery data.These models fully incorporate uncertainties in age classifications of tagged fi